Uncle Drew

Charles Stone III

Director

Kyrie Irving

Uncle Drew

Lil Rel Howery

Dax

Shaquille O'Neal

Big Fella

Chris Webber

Preacher

Reggie Miller

Lights

Nate Robinson

Boots

Lisa Leslie

Betty Lou

Erica Ash

Maya

Tiffany Haddish

Jess

Nick Kroll

Mookie

Aaron Gordon

Casper

Mike Epps

Louis

J.B. Smoove

Angelo

Wesley Witherspoon

Mario

Thomas Mills

Duke Tango

Selema Masekela

Sal Masekela

Adam Lazarre-White

Frankie The Tournament Director

Adam Lazarre-White

Narrator

Lavar Walker

Marty the Manager

Jay Longino

Writer